Proprietary Technology

Liposomal technology

Liposomes are microscopic spherical vesicles that form when phospholipids are hydrated. When mixed in water under low shear conditions, the phospholipids arrange themselves in sheets, the molecules aligning side by side.

These sheets then join to form a bilayer membrane that encloses some of the water in a phospholipid sphere. Typically, several of these vesicles will form a multilamellar (multi-layered) structure of concentric phospholipid spheres separated by layers of water.

In so doing, liposomes enable water-soluble and water insoluble materials to be used together in a single formulation. Endovasc’s technology refines this process, producing stable, multilamellar liposomes with special characteristics. The resulting liposomes hold the materials together in a microsphere with controlled release of the encapsulated ingredients.

This liposome delivery technology is used to:

• Slow the release of the active agent.

• Increase the bioavailability of the drugs.

• Increase the shelf life of the drug.

• Increase circulating half-life (protect drug from degradation).